Solid phase oligonucleotide synthesis using phosph

专利名称：Solid phase oligonucleotide synthesis using

phospholane intermediates

发明人：Wojciech J. Stec,Andrzej Grajkowski,Bogdan

Uznanski

申请号：US07/826929申请日：19920123公开号：US05512668A公开日：19960430

摘要：Methods and compounds are provided for solid phase synthesis of

oligonucleotides and related polymers by condensing protected monomer- O- [1,3,2-dichalcogen-substituted-phospholane] synthons in the presence of a catalytic base.Compounds of the invention include 2-N-substituted-1, 3,2- dichalcogen-substituted-phospholane precursors of the above synthons, the protected monomer-O-[1,3,2-dichalcogen-substituted-phospholane] synthons, and P-chiral oligonucleotides andrelated P-chiral polymers.

申请人：POLISH ACADEMY OF SCIENCES

代理人：Stephen C. Macevicz

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